What is the mechanism by which bats carry a large number of viruses without getting sick?

Bats are known to mediate

Ebola virus , which causes Ebola hemorrhagic fever , SARS-CoV , which causes severe acute respiratory syndrome (SARS), and MERS-CoV, which causes Middle East respiratory syndrome (MERS) , and will continue to be prevalent throughout 2020. SARS-CoV-2, which causes the new type of coronavirus infection (COVID-19), is also thought to be a bat-derived virus. Researchers in Singapore have discovered a new mechanism for the mystery that bats carry various viruses but do not get sick.

Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats | PNAS

Duke-NUS study uncovers why bats excel as viral reservoirs without getting sick

A research team led by Professor Lin-Fa Wang of the National University of Singapore's Graduate School of Medicine made a new report on the causes of bats carrying the zoonotic virus but not getting sick. Professor Wang and colleagues investigated three types of bats, the black fruit bat , the Cave nectar bat , and the David bat , and attempted to elucidate the mechanism of activity of proteins that play important roles in mediating immune and inflammatory responses.

As a result of investigation, a mechanism that lowers the level of ' caspase-1 ', which plays a central role in many processes including cell death and inflammation, and ' interleukin-1β ', which is a kind of inflammatory cytokine that causes an inflammatory reaction. It turns out that the bat has. Furthermore, it was found that by finely adjusting the balance between caspase-1 and interleukin-1β, it also has a function of inhibiting the maturation of interleukin-1β.

Professor Wang explained that these mechanisms are the reason why bats carry the zoonotic virus but do not infect it. 'In the case of humans, suppressing the overactive inflammatory response is due to aging. It is known to prevent decline and prolong life. This discovery may lead to the development of new strategies for controlling and treating infectious diseases in the human body. '

in Science,   Creature, Posted by darkhorse_log